Science in court: Arrested development

Science in the court.

The nude mouse has several advantages for the study of human tumours. Compared to adult cancers (Sharkey et al., 1978), paediatric tumours have been less extensively xenografted into nude mice (Helson, 1982). The only large series was published by Neely et al. (1983). Most infantile solid tumours are considered embryonic because of the age at which they occur and their potential for differentia...

Health care in "arrested development": Naylor.

Econometric Forecasting and the Science Court

A recent proposal in Science (reviewed by Boffey 1976) called for a science court to improve the advocacy procedure (see also Callen 1976; Presidential Advisory Group 1976). Rather than wait for different viewpoints to appear in the literature, scientists would be called to act as advocates, much as in a court of law. Such a procedure should speed up the collection and examination of the evidence.

Neurodegeneration: A Case of Arrested Development?

The neurodegenerative disease Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine expansion disorder characterized by the death of Purkinje neurons in the brain. In this issue, Serra et al. (2006) implicate the impaired function of the orphan nuclear receptor RORalpha in SCA1 pathogenesis. Their intriguing results suggest that derailing a transcription program during embryonic development m...

Arrested pneumatization: witness of paranasal sinuses development?

OBJECTIVES Recent radiological studies have demonstrated that formation of the sphenoid sinus is preceded by a phase of fatty transformation of the bone marrow, and then by a phase of fat involution prior to the appearance of an aerated cavity and that this process can sometimes be interrupted, resulting in the persistence of images of arrested pneumatisation. The objective of the study was to ...